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  1. What are the symptoms of sympathetic ophthalmia (SO)?
  2. What are the critical signs?
  3. What are the differentials?
  4. What are the useful workups?
  5. How do you treat SO?
  6. How should one be followed up?
  7. How do I get more information?

What are the symptoms of sympathetic ophthalmia (SO)?

The symptoms of sympathetic ophthalmia include: bilateral eye pain, photophobia, decreased vision (near vision is often affected before distance vision), red eye. A history of penetrating trauma or intraocular surgery to one eye (usually 4 to 8 weeks before, but the range is from 5 days to 66 years, with 90% occurring within 1 year) may be elicited.

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What are the critical signs?

Any inflammation in the uninvolved eye after unilateral ocular trauma is suspicious. Your ophthalmologist will see bilateral severe anterior-chamber reaction with large mutton-fat keratic precipitates, small depigmented nodules at the level of the retinal pigment epithelium (Dalen-Fuchs' nodules), and thickening of the uveal tract. Signs of previous injury or surgery in one eye are usually present, including indications of previous laser therapy or cryotherapy.

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What are the differentials?

Sympathetic ophthalmia may be mistaken for VOgt-Koyanagi-Harada syndrome (VKH), phacoanaphylactic endophthalmitis, sarcoidosis, and syphilis.

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What are the useful workups?

History may reveal a prior eye surgery or injury. The presence of venereal disease and difficulty of breathing may be helpful. A complete ophthalmic examination including a dilated retinal examination should be performed. Blood extraction for the following: complete blood count (CBC), rapid plasma reagin (RPR), FTA-ABS, with or without angiotension converting enzyme (ACE) level if sarcoidosis is a serious consideration. A chest radiograph may be requested to evaluate for tuberculosis or sarcoidosis. A flourescein angiography or B-scan ultrasonography or both may help in confirming the diagnosis.

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How do you treat SO?

The best way to treat SO is to prevent it. The enucleation of a blind, traumatized eye before a sympathetic reaction can develop (usually within 7 to 14 days of the trauma). If sympathetic ophthalmia develops, enucleation may still be beneficial, regardless of the time since the trauma.

Inflammation is controlled with steroids; the dose depends on the severity of the inflammation. In moderate to severe cases, the following regimen can be used initially. Steroids are tapered slowly as the condition improves. A combination of topical, periocular, systemic steroids are usually necessary. Topical cycloplegic agents are also used. If steroids are ineffective or contraindicated, an immunosuppressive agent may be tried.

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How should one be followed up?

Patients with SO are followed up every 1 to 7 days initially, to monitor the effectiveness of therapy. As the condition improves, the follow-up interval may be extended to every 3 to 4 weeks. Intraocular pressure must be monitored closely. Steroids should be maintained for 3 to 6 months after all signs of inflammation have resolved. Because of the possibility of recurrence, periodic checkups are essential.

 

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How do I get more information?

 

There are several ways of reaching the ophthalmologists of EYE REPUBLIC Ophthalmology Clinic:
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WEBSITES.

     http://www.EyeRepublic.com.ph - EYE REPUBLIC Ophthalmology Clinic
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     http://www.Cataract.com.ph  - Cataract Surgery Resource
     http://www.Eye.com.ph - Eye Information Online
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     http://www.Retina.com.ph - Retina Surgery Resource
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EYE REPUBLIC Ophthalmology Clinic

Manila

3/F Don Santiago Building Units 309-310

1344 Taft Avenue, Ermita

Manila, 1000 Philippines

Direct and Fax: (632) 536-2398

Trunk Line: (632) 523-8271 to 79 local 30

Mobile: (63917) 899-2020

Map and directions 

EYE REPUBLIC Ophthalmology Clinic

Asian Hospital and Medical Center

5/F Medical Office Building (MOB) Suite 509

2205 Civic Drive, Filinvest, Alabang

Muntinlupa City, 1781 Philippines

Direct: (632) 771-9253

Direct and Fax: (632) 771-9254

Mobile: (63917) 795-2020

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EYE REPUBLIC Ophthalmology Clinic

Medical City

6/F Medical Arts Tower Inc (MATI) Suite 602

MERALCO Compound, Ortigas Avenue

Pasig City, 1604, Philippines

Direct and Fax: (632) 632-7846

Mobile: (63917) 537-2020

Map and directions

EYE REPUBLIC Ophthalmology Clinic

St. Luke's Medical Center

6/F Cathedral Heights Building Complex (CHBC)

North Tower Suite 614

279 E. Rodriguez Sr. Boulevard

Quezon City, 1102 Philippines

Direct and Fax: (632) 407-3883

Mobile: (63917) 855-2020

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CLINIC HOURS

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Monday to Saturday 9:00 AM to 6:00 PM

All clinics are closed on Sundays and Holidays

 

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SYMPATHETIC OPHTHALMIA information compiled by Dr. Manolette R. Roque and initially uploaded on June 3, 2005.

Last updated on September 14, 2007.

 

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Philippines

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