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What is HSV? 

How do I get HSV? 

What are the clinical manifestations of HSV?

How is HSV diagnosed?

How is ocular herpes managed?

How do I get more information?

 


 

What is HSV?

 

The herpes simplex virus or HSV is a human pathogen that can infect many end organs, one of which is the human eye. Typically, there are two types of infections caused by these viruses: HSV Type 1 and HSV type 2. Type 1 infections usually involve the oropharynx or mouth area. Type 2 infections on the other hand have a predilection for the genital region. Typically, ocular HSV is caused by type 1 rather than type 2 HSV.

 

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How do I get HSV?

 

Humans are the only known hosts of the herpes simplex virus. It is for this reason that the disease is commonly seen in the human population.  Major entry points for the virus to cause infection are the mucous membranes and external skin. It is believed that close personal contact is necessary for the spread of HSV.

 

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What are the clinical manifestations of HSV?

 

Initial infection with HSV can have no symptoms, with the virus remaining in its latent phase within the sensory ganglia. However, psychological stress, systemic infections, sunlight exposure, menstrual period and eye injuries are all believed to trigger HSV reactivation.

 

Typically, the corneal epithelium (epithelial keratitis) is involved wherein ulcerations of the corneal surface may occur. In these cases, patients may complain of increased sensitivity to light (photophobia), pain, watery discharge and blurred vision. Both the corneal stroma (stromal keratitis) and the corneal endothelium (endothelitis) may likewise be affected.

 

HSV may also infect the eyelids/eyelid margins (blepharitis) and conjunctiva (conjunctivitis). Patients with HSV blepharitis develop vesicles involving the eyelid area. The typical lesions evolve from vesicular eruptions, to ulcerations, then to areas of crusting which usually do not leave scars unless secondarily infected. On the other hand, HSV conjunctivitis presents as eye redness with discharge that is watery. Both HSV blepharitis and conjunctivitis may progress to keratitis so early recognition and institution of proper management is important.

 

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How is HSV diagnosed?

 

Viral cultures help aid in the diagnosis of ocular HSV but these are rarely done. The diagnosis of primary and recurrent HSV relies mostly on a thorough ophthalmic examination to look for signs that point to an active infection.

 

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How is ocular herpes managed?

 

Topical antiviral medications are instituted for active HSV ocular infections. Steriods are typically avoided in these cases since they suppress the immune status and may possibly lead to virus proliferation. For cases of stromal infection and inflammation of the inner parts of the eye, steroids may be indicated although judicious use is always advised. Oral antivirals are used if the infection is severe and located in areas which cannot be reached by topical medications.

 

Since the goal of therapy is to remove the viral particles, mechanical debridement of epithelial lesions may also be done. Corneal transplants are indicated when there is corneal perforation and if there is persistent disease that does not respond to other modalities. Post operative course of these eyes are however, guarded and standard care must be modified in order to ensure graft survival.

 

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How do I get more information?

 

There are several ways of reaching the ophthalmologists of EYE REPUBLIC Ophthalmology Clinic:
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EYE REPUBLIC Ophthalmology Clinic

Manila

3/F Don Santiago Building Units 309-310

1344 Taft Avenue, Ermita

Manila, 1000 Philippines

Direct and Fax: (632) 536-2398

Trunk Line: (632) 523-8271 to 79 local 30

Mobile: (63917) 899-2020

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EYE REPUBLIC Ophthalmology Clinic

Asian Hospital and Medical Center

5/F Medical Office Building (MOB) Suite 509

2205 Civic Drive, Filinvest, Alabang

Muntinlupa City, 1781 Philippines

Direct: (632) 771-9253

Direct and Fax: (632) 771-9254

Mobile: (63917) 795-2020

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EYE REPUBLIC Ophthalmology Clinic

Medical City

6/F Medical Arts Tower Inc (MATI) Suite 602

MERALCO Compound, Ortigas Avenue

Pasig City, 1604, Philippines

Direct and Fax: (632) 632-7846

Mobile: (63917) 537-2020

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EYE REPUBLIC Ophthalmology Clinic

St. Luke's Medical Center

6/F Cathedral Heights Building Complex (CHBC)

North Tower Suite 614

279 E. Rodriguez Sr. Boulevard

Quezon City, 1102 Philippines

Direct and Fax: (632) 407-3883

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All clinics are closed on Sundays and Holidays

 

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HSV KERATITIS information compiled by Dr. Johann Reyes and initially uploaded on February 11, 2006.

Last updated on September 14, 2007.

 

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