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What is APMPPE?
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What are the symptoms of APMPPE?
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What is the therapy and prognosis
for APMPPE?
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How do I get more information?
What is APMPPE?
APMPPE
is a syndrome of multiple, large, plaquelike lesions at the level of the RPE
that are associated with temporary visual loss.
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What are the symptoms of APMPPE?
APMPPE usually manifests with sudden onset of
blurring or flashing lights in a patient less than 30 years of age. There is no
sex predilection. Most cases are bilateral and occur simultaneously in both
eyes.
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What is the therapy and prognosis for APMPPE?
Most patients with APMPPE have an excellent
prognosis for vision and do not necessitate therapy. Corticosteroids given
systemically are advocated by some ophthalmologists.
Fifteen patients (28 eyes) with APMPPE were reassessed at
Westmead Hospital Eye Clinic (Westmead, NSW, Australia) up to 18 years (mean 6.4
years) after their initial presentation to one of the authors (PM) or to their
private ophthalmologist. Stereo retinal photographs and visual acuities taken at
the initial presentation were compared with those obtained at the most recent
follow-up visit. The last recorded visual acuity was 6/6 or better in 16 eyes
(57%), 6/9-6/18 in four eyes (14%), 6/24-6/60 in five eyes (18%) and worse than
6/60 in three eyes (11%). Nine patients (60%) were treated with oral prednisone
during the acute episode with little therapeutic effect observed. Six patients
(40%) described a prodromal flu-like illness. This study suggests that the
long-term visual outcome following an acute episode of APMPPE may not be as
favourable as initially portrayed by Gass. It confirms other study findings
suggesting that APMPPE may not be a benign self-limiting disease. Older age at
onset and initial foveal involvement were associated with a worse visual
outcome.
Roberts TV, Mitchell P. Acute posterior multifocal placoid
pigment epitheliopathy: a long-term study.
Aust N Z J Ophthalmol. 1997
Nov;25(4):277-81.
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EYE REPUBLIC
Ophthalmology Atlas
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EYE REPUBLIC Ophthalmology Clinic
Manila
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EYE REPUBLIC
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EYE REPUBLIC
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APMPPE information
compiled by
Manolette Roque, M.D. and initially uploaded on September 27, 2005.
Last updated on
September 13, 2007. |
